Some studies have concluded that those who do successfully quit smoking may gain weight. “Weight gain is not likely to negate the health benefits of smoking cessation, but its cosmetic effects may interfere with attempts to quit.” (Williamson, Madans et al., 1991).
Therefore, drug companies researching smoking-cessation medication often measure the weight of the participants in the study.
In 2009, it was found that smoking over expresses the gene AZGP1 which stimulates lipolysis, which is the possible reason why smoking cessation leads to weight gain.
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