Key Enzyme Allows Eating of Fat-Diet Without Becoming Fat

A University of California study have found an enzyme when disabled, it allows consumption of high-fat diet without getting fat.

The researchers tested it on mice, disabling the enzyme in question within the fat cells, to much success.

This enzyme is the key regulator of fat metabolism and body weight.

To be specific, the enzyme is called adipose-specific phospholipase A2 (AdPLA).

It is found commonly in fat tissue.

The study had two groups of mice, one lacking AdPLA enzyme, and the other a controlled mice.

After 64 weeks, the mice with AdPLA deficient weighs only 39.1 grams, while the other mice group weighs 73.7 grams.

So the lack of AdPLA enzyme results in higher fat breakdown, as levels of PGE2 (prostaglandin E2) are decreased.

Note however that the number of fat cells remains unchanged.

This study has potential for future treatment and study for human obesity.